The Top 200 Prescribed Drugs

200 Ranitidine (Zantac®) – Top 200 Prescribed Drugs

Play
Share!

Share this Podcast

MyCast

MyCast

MyCast Subscription

The Top 200 Prescribed Drugs

Joshua Hollingsworth

Description: Short, concise, daily episodes covering 1 drug at a time.

Most Recent Post

200 Ranitidine (Zantac®) – Top 200 Prescribed Drugs

Play Download media
Note: 199 Pravastatin (Pravachol®) has been covered in a previous episode (105)  Today’s episode was sponsored by Lexi-Comp.  To access the same great drug information that was used in today’s podcast or for a chance to win an iPod touch and free Lexi-Comp software, please visit www.lexi.com/top200 (http://thestudentpharmacist.com/www.lexi.com/top200). And, as a special offer to all top200 listeners, use promotion code TOP200 to save 20% on your software purchase today! 200 Ranitidine (Zantac®) (http://thestudentpharmacist.com/wp-content/uploads/200_Ranitidine.mp3) Episode Notes (References Below) * Brand/Generic: * Generic: Ranitidine (Available) * Brand: Zantac® * Mechanism of Action * Histamine H2 Antagonsist (H2 Blocker) * Inhibits gastric acid secretion by blocking H2-receptors on the gastric parietal cells * Indication(s) * Duodenol or gastric ulcer * GERD (gastroesophogeal reflux disease) * Erosive esophagitis * Hypersecretory conditions * H. Pylori eradication (as part of a multidrug regimen) * Heart burn and indigestion * Sour stomach * Dosage form(s) * Capsule * 150, 300 mg * Premixed infusion solution * 50 mg * Injection solution * 25 mg/mL * Oral Syrup * 15 mg/mL * Tablet * 75 [OTC], 150 [OTC], 300 mg * Effervescent tablet for solution * 25 mg * Adult Dosing * Depends on the indication * For most indications (GERD, ulcers, H. pylori, erosive esophagitis maintenance) * Usual dose is 150 mg twice daily * For erosive esophagitis treatment: 150 mg 4 times/day * For OTC use in preventing heartburn: * 75 mg 30-60 min before eating or drinking food that may cause heartburn. * Max dose: 150 mg in 24 hours * Should not self treat for > 14 days * See a doctor for long-term treatment * For patients with renal impairment: Creatinine clearance (CrCl) < 50 mL/min: * Oral 150 mg every 24 hours * IV 50 mg every 18-24 hours * Adjust the dose carefully if necessary * Pharmacokinetics * ~50% absorption * Metabolized in the liver * Time to peak: 2-3 hours * Excreted in the urine as unchanged drug and the feces as metabolites * Contraindication(s) * Hypersensitivity * Precaution(s) * Long term use may lead to vitamin B12 deficiency * Confusion, especially in elderly patients > 50 years of age, although rare, has been documented with the use of ranitidine * Fully reversibly, and usually clears within 4 days after discontinuation * Relief of symptoms does not eliminate the presence of a gastric tumor or malignangy * Adjust dose renal impairment with a CrCl < 50 mL/min * Avoid use in patients with a history of actue porphyria * Zantac® could exacerbate an attack * Adverse Drug Reactions * Most common * Headache * GI upest * Confusion * Dizziness * MAJOR Drug Interactions * Avoid use with either Delavirdine or Erlotinib * P-Glycoprotein inhibitors may increase the effects of ranitidine * Pregnancy Category/Breast feeding * Category B * Use with caution in breast feeding (does enter breast milk) * Safety & Efficacy Monitoring Parameters * Serum creatinine and renal function * Signs and symptoms of peptic ulcer disease * Occult blood with GI bleeding * Relief of symptoms * Major Counseling Points * If taking ranitidine to prevent heart burn, then you should take the dose 30-60 minutes before eating foods that may lead to heartburn * Unless instructed to do so by your doctor, do not exceed 150 mg in a 24 hour period * Do not self treat for > 2 weeks * If longer treatment is needed, it is recommended to see a doctor to make sure there is no other underlying cause of the symptoms * Make sure the patient knows dosing schedule, usually twice daily * Common side effects include GI upset, headache, and dizziness

Last 5 Posts

198 Verapamil (Isoptin®, Verelan®) – Top 200 Prescribed Drugs

Play Download media
 Today’s episode was sponsored by Lexi-Comp.  To access the same great drug information that was used in today’s podcast or for a chance to win an iPod touch and free Lexi-Comp software, please visit www.lexi.com/top200 (http://thestudentpharmacist.com/www.lexi.com/top200)...

197 Benazepril (Lotensin®) – Top 200 Prescribed Drugs

Play Download media
Today’s episode was sponsored by Lexi-Comp.  To access the same great drug information that was used in today’s podcast or for a chance to win an iPod touch and free Lexi-Comp software, please visit www.lexi.com/top200 (http://thestudentpharmacist.com/www.lexi.com/top200)...

196 Ramipril (Altace®) – Top 200 Prescribed Drugs

Play Download media
Note: 195 Naproxen (Aleve®) has been covered in a previous episode (135)

Today’s episode was sponsored by Lexi-Comp.  To access the same great drug information that was used in today’s podcast or for a chance to win an iPod touch and free Lexi-Comp...

194 Lidoderm® (Lidocaine) – Top 200 Prescribed Drugs

Play Download media
Today’s episode was sponsored by Lexi-Comp.  To access the same great drug information that was used in today’s podcast or for a chance to win an iPod touch and free Lexi-Comp software, please visit www.lexi.com/top200 (http://thestudentpharmacist.com/www.lexi.com/top200)...

190 Evista® (Raloxifene) – Top 200 Prescribed Drugs

Play Download media
Today’s episode was sponsored by Lexi-Comp.  To access the same great drug information that was used in today’s podcast or for a chance to win an iPod touch and free Lexi-Comp software, please visit www.lexi.com/top200 (http://thestudentpharmacist.com/www.lexi.com/top200)...

Guest Book

Subscribe & Follow

NMX and Nab Show, Las Vegas, April 2015