The Top 200 Prescribed Drugs

200 Ranitidine (Zantac®) – Top 200 Prescribed Drugs

Play
Play
Share!

Share this Podcast

MyCast

MyCast

MyCast Subscription

The Top 200 Prescribed Drugs

Joshua Hollingsworth

Description: Short, concise, daily episodes covering 1 drug at a time.

Most Recent Post

200 Ranitidine (Zantac®) – Top 200 Prescribed Drugs

Play Download media

Note: 199 Pravastatin (Pravachol®) has been covered in a previous episode (105)

 Today’s episode was sponsored by Lexi-Comp.  To access the same great drug information that was used in today’s podcast or for a chance to win an iPod touch and free Lexi-Comp software, please visit www.lexi.com/top200.

And, as a special offer to all top200 listeners, use promotion code TOP200 to save 20% on your software purchase today!

200 Ranitidine (Zantac®)

Episode Notes (References Below)

  • Brand/Generic:
    • Generic: Ranitidine (Available)
    • Brand: Zantac®
  • Mechanism of Action
    • Histamine H2 Antagonsist (H2 Blocker)
    • Inhibits gastric acid secretion by blocking H2-receptors on the gastric parietal cells
  • Indication(s)
  • Duodenol or gastric ulcer
  • GERD (gastroesophogeal reflux disease)
  • Erosive esophagitis
  • Hypersecretory conditions
  • H. Pylori eradication (as part of a multidrug regimen)
  • Heart burn and indigestion
  • Sour stomach
  • Dosage form(s)
    • Capsule
      • 150, 300 mg
    • Premixed infusion solution
      • 50 mg
    • Injection solution
      • 25 mg/mL
    • Oral Syrup
      • 15 mg/mL
    • Tablet
      • 75 [OTC], 150 [OTC], 300 mg
    • Effervescent tablet for solution
      • 25 mg
  • Adult Dosing
    • Depends on the indication
    • For most indications (GERD, ulcers, H. pylori, erosive esophagitis maintenance)
      • Usual dose is 150 mg twice daily
    • For erosive esophagitis treatment: 150 mg 4 times/day
    • For OTC use in preventing heartburn:
      • 75 mg 30-60 min before eating or drinking food that may cause heartburn.
      • Max dose: 150 mg in 24 hours
      • Should not self treat for > 14 days
        • See a doctor for long-term treatment
    • For patients with renal impairment: Creatinine clearance (CrCl) < 50 mL/min:
      • Oral 150 mg every 24 hours
      • IV 50 mg every 18-24 hours
      • Adjust the dose carefully if necessary
  • Pharmacokinetics
    • ~50% absorption
    • Metabolized in the liver
    • Time to peak: 2-3 hours
    • Excreted in the urine as unchanged drug and the feces as metabolites
  • Contraindication(s)
    • Hypersensitivity
  • Precaution(s)
    • Long term use may lead to vitamin B12 deficiency
    • Confusion, especially in elderly patients > 50 years of age, although rare, has been documented with the use of ranitidine
      • Fully reversibly, and usually clears within 4 days after discontinuation
    • Relief of symptoms does not eliminate the presence of a gastric tumor or malignangy
    • Adjust dose renal impairment with a CrCl < 50 mL/min
    • Avoid use in patients with a history of actue porphyria
      • Zantac® could exacerbate an attack
  • Adverse Drug Reactions
    • Most common
      • Headache
      • GI upest
      • Confusion
      • Dizziness
  • MAJOR Drug Interactions
    • Avoid use with either Delavirdine or Erlotinib
    • P-Glycoprotein inhibitors may increase the effects of ranitidine
  • Pregnancy Category/Breast feeding
    • Category B
    • Use with caution in breast feeding (does enter breast milk)
  • Safety & Efficacy Monitoring Parameters
    • Serum creatinine and renal function
    • Signs and symptoms of peptic ulcer disease
    • Occult blood with GI bleeding
    • Relief of symptoms
  • Major Counseling Points
    • If taking ranitidine to prevent heart burn, then you should take the dose 30-60 minutes before eating foods that may lead to heartburn
      • Unless instructed to do so by your doctor, do not exceed 150 mg in a 24 hour period
      • Do not self treat for > 2 weeks
        • If longer treatment is needed, it is recommended to see a doctor to make sure there is no other underlying cause of the symptoms
    • Make sure the patient knows dosing schedule, usually twice daily
    • Common side effects include GI upset, headache, and dizziness
    • Let you doctor or pharmacist know if ranitidine causes any mental confusion
    • As always, report any severe, persistent, or intolerable side effects

References:

  1. Ranitidine. In: Lexi-Comp Online [Internet]. Hudson, OH: Lexi-Comp, Inc. [updated 2011, cited 2011 Aug 29]. [about 8 p.]. Available from http://online.lexi.com/crlsql/servlet/crlonline
  2. Zantac®. In: Pharmacy Drug Cards 23rd Edition. SFI Medical Publishing; 2007. Available from: http://www.sfirx.com/view_product.php?id=17
  3. Ranitidine. In: Epocrates Online [Internet]. San Mateo, CA: Epocrates, Inc. [Updated 2011, cited 2011 Aug 29].  [About 6 p.]. Available from: https://online.epocrates.com/noFrame/
  4. Bartholow M. Top 200 Prescription Drugs of 2009 [Internet]. Plainsboro (NJ). Pharmacy Times. 2010 May 11 [Cited 2010 May 27]. Available from: http://www.pharmacytimes.com/media/pdf/PHTM_36.pdf


Yeah. So we finished the top 200! I want to thank you all for listening.  And don’t worry. I do have some more pharmacy related podcast in the works that I hope you will be interested in. Be sure to check TheStudentPharmacist.com in the next couple of weeks for more information. Also, I hope you have learned  a little something and have gotten some useful information out of the podcast.  If you have can please share it with others who may be interested AND consider giving a small donation towards this podcast and future podcast like it. There is a donate button now on the studentpharmacist.com.  Every little bit helps. Thanks and see you next time!

dtsv.dtse_post_696_permalink = 'http://thestudentpharmacist.com/?p=696'; dtsv.dtse_post_696_title = '200 Ranitidine (Zantac®) – Top 200 Prescribed Drugs';

Last 5 Posts

198 Verapamil (Isoptin®, Verelan®) – Top 200 Prescribed Drugs

Play Download media
 Today’s episode was sponsored by Lexi-Comp.  To access the same great drug information that was used in today’s podcast or for a chance to win an iPod touch and free Lexi-Comp software, please visit www.lexi.com/top200 (http://thestudentpharmacist.com/www.lexi.com/top200)...

197 Benazepril (Lotensin®) – Top 200 Prescribed Drugs

Play Download media
Today’s episode was sponsored by Lexi-Comp.  To access the same great drug information that was used in today’s podcast or for a chance to win an iPod touch and free Lexi-Comp software, please visit www.lexi.com/top200 (http://thestudentpharmacist.com/www.lexi.com/top200)...

196 Ramipril (Altace®) – Top 200 Prescribed Drugs

Play Download media
Note: 195 Naproxen (Aleve®) has been covered in a previous episode (135)

Today’s episode was sponsored by Lexi-Comp.  To access the same great drug information that was used in today’s podcast or for a chance to win an iPod touch and free Lexi-Comp...

194 Lidoderm® (Lidocaine) – Top 200 Prescribed Drugs

Play Download media
Today’s episode was sponsored by Lexi-Comp.  To access the same great drug information that was used in today’s podcast or for a chance to win an iPod touch and free Lexi-Comp software, please visit www.lexi.com/top200 (http://thestudentpharmacist.com/www.lexi.com/top200)...

190 Evista® (Raloxifene) – Top 200 Prescribed Drugs

Play Download media
Today’s episode was sponsored by Lexi-Comp.  To access the same great drug information that was used in today’s podcast or for a chance to win an iPod touch and free Lexi-Comp software, please visit www.lexi.com/top200 (http://thestudentpharmacist.com/www.lexi.com/top200)...

Guest Book

Subscribe & Follow

Average Rating

5 stars
4 stars
3 stars
2 stars
1 star
(0 ratings)